This resource brings together world leaders in research on depression, to discuss, for the first time, in an interdisciplinary setting, both classical and innovative ideas to understand this devastating disorder. It presents neurobiological, psychological, genetic and evolutionary models, with a particular emphasis on the mechanisms linking the brain to the endocrine and the immune systems, and therefore linking depression to physical health.
Table of Contents
- Chapter 1 Experiencing depression
- Chapter 2 Depression in the medically ill
- Chapter 3 Explaining depression: neuroscience is not enough, evolution is essential
- Chapter 4 Evolutionary genetics of affective disorders
- Chapter 5 Genetic factors in stress and major depression
- Chapter 6 Bipolar disorder and unipolar depression: what is the genetic relationship?
- Chapter 7 The significance of dysregulated basal glucocorticoid pulsatility in affective disorders
- Chapter 8 Early life programming of affective function
- Chapter 9 Modelling depression by GR mutant animals?
- Chapter 10 Cytokines and depression: experimental evidence and intermediate mechanisms
- Chapter 11 Do depression, stress, sleep disruption, and inflammation alter hippocampal apoptosis and neurogenesis?
- Chapter 12 The role of the medial prefrontal cortex in mediating resistance and vulnerability to the impact of adverse events
- Chapter 13 Is it all monoamines?
- Chapter 14 The role of affective processing in vulnerability to and resilience against depression
- Chapter 15 PTSD and HPA axis: same hormones, different disorders
- Chapter 16 Neuroendocrine and immune crosstalk in major depression
- Chapter 17 Neuropsychiatric effects of IFN-alpha: relevance to depression
- Chapter 18 Depression and coronary heart disease
- Chapter 19 Does depression induce pain and fatigue?
- Chapter 20 Explaining the association between depression and mortality: a life course epidemiology approach
- Chapter 21 Depression: unipolar or bipolar, what’s the difference (and what does it matter anyway)?
- Chapter 22 Can neuroimaging help distinguish bipolar depression from major depressive disorder?
- Chapter 23 Pharmacogenetics of antidepressant response
- Chapter 24 Can the EEG be used to predict antidepressant response?
- Chapter 25 Can we use magnetic/electric fields to help in treatment-resistant depression?
- Chapter 26 Antiglucocorticoids in the treatment of affective disorders: from preclinical to clinical studies
- Chapter 27 How can we use current knowledge to improve antidepressant treatments?