Chasing Pain: The Search for a Neurobiological Mechanism of Pain

Chasing Pain: The Search for a Neurobiological Mechanism of Pain

Kenneth L. Casey

Print publication date: Feb 2019

ISBN: 9780190880231

Publisher: Oxford University Press


By several measures, no human experience is more important than pain. Chasing Pain discusses the evolution of scientific and clinical evidence that supports contemporary concepts of how pain is created by the nervous system. These concepts influence medical practice, neuroscientific research, and philosophical ideas about pain and other neurological functions. Historically, pain has been conceived as emerging either from an undefined pattern of neural activity or from anatomically localized and physiologically unique structures in the nervous system. Research during the early and middle 20th century showed that pain normally requires both sensory detectors of noxious events (nociceptors) and brain mechanisms that generate emotional experience. Realistic models of pain neurobiology must also consider that the normally tight link between pain and tissue damage is strongly affected by several neurological diseases, emotionally compelling circumstances, complex cognitive processes, and pain itself. As one example of physiological pain modulation, readers may access the author’s videos of surgery performed with acupuncture as the sole analgesic method. Chasing Pain reviews the neuroscientific research and clinical experience that has, over time, greatly enriched our understanding of pain neurobiology, guided medical practice, and influenced contemporary concepts of neurological functions. The limitations of our current conceptual models of pain are exemplified by considering several common, clinically challenging conditions that remain very poorly understood.