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Local Administration of Fresh Frozen Plasma and Platelets in the Critically Ill Patient 

Local Administration of Fresh Frozen Plasma and Platelets in the Critically Ill Patient
Chapter:
Local Administration of Fresh Frozen Plasma and Platelets in the Critically Ill Patient
Author(s):

Salim E. Abboud

, Dean A. Nakamoto

, and John R. Haaga

DOI:
10.1093/med/9780199986071.003.0104
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date: 29 July 2021

The locally injected blood elements (LIBE) technique represents a useful alternative to systemic administration of blood products to reduce the risk of periprocedural hemorrhage in coagulopathic patients. The LIBE technique results in the creation of a “seroma” of platelets and/or blood products along the expected needle or instrument path to allow a high-quality blood clot to form, and it requires relatively less blood products compared to the more traditional systemic administration technique. Indications for LIBE include and expand on those for systemic administration of blood products to reverse pre-procedural coagulopathy, including contraindications to systemic reversal of pharmacologic anticoagulation, precarious fluid volume status, severe coagulopathy unlikely to normalize with systemic administration of blood products, patient history of adverse reaction to systemic administration of blood products, and limited availability of the desired blood product.

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