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Adjuvant Therapy for High-Risk Melanoma: Radiation Therapy 

Adjuvant Therapy for High-Risk Melanoma: Radiation Therapy
Adjuvant Therapy for High-Risk Melanoma: Radiation Therapy

Michael D. Chuong

, Mohammad K. Khan

, and Nikhil G. Rao

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date: 12 July 2020

While surgical management is the mainstay of treatment for patients with invasive cutaneous melanoma, adjuvant radiation therapy (RT) to the primary site and/or the adjacent nodal regions can provide significant benefit to patients at high risk for local or regional recurrence. Due to early preclinical and clinical reports that melanoma is radioresistant, many clinicians have been hesitant to recommend RT. However, subsequent studies have shown melanoma to be responsive to RT and RT to be a critical component of the comprehensive treatment for select patients with cutaneous melanoma. The use of radiotherapy in the future for melanoma is likely to play a greater role, especially combined with newer emerging systemic agents such as CTLA4 inhibitors, PD-1 inhibitors, BRAF inhibitors, and potential radiation sensitizers such as the MEK inhibitor, trametinib.

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