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Immunotherapy in Melanoma 

Immunotherapy in Melanoma
Chapter:
Immunotherapy in Melanoma
Author(s):

Maggie Diller

and Ragini R. Kudchadkar

DOI:
10.1093/med/9780199971015.003.0006
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date: 22 September 2019

Immune therapies have revolutionized the treatment of metastatic melanoma, and more patients are now long-term survivors of this disease. Questions still remain regarding the best sequencing and combination of treatments. Additionally, studies are underway to identify biomarkers that may serve as predictors of response and help further guide and individualize therapy. With regard to adjuvant treatment, interferon remains the standard of care. However, given the impact of immunomodulation on stage IV disease and early studies suggesting the efficacy of such medications as ipilimumab as adjuvant therapy, results from ongoing trials may change the way we treat patients in the adjuvant setting. Toxicities for the various medications can be expansive. Early recognition and management of adverse events is key to the safe and effective use of all therapies and in preventing long-term morbidity and mortality.

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