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Melanoma Pathology 

Melanoma Pathology
Chapter:
Melanoma Pathology
Author(s):

Carlos Prieto-Granada

, Nicole Howe

, and Timothy McCardle

DOI:
10.1093/med/9780199971015.003.0002
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date: 06 July 2020

Melanocytes are neural-crest-derived cells that are vital in the skin homeostasis, being responsible for the protection of the keratinocytes from harmful solar UV radiation via production and transfer of melanin. Normally, melanocytes are located in the basilar layer of the epidermis following a melanocyte-to-keratinocyte ratio of approximately 1:10 with considerable variation, depending on anatomical site and degree of sun exposure. Melanocytic lesions characteristically demonstrate quite protean clinical and pathological presentations and represent a wide spectrum that encompasses an immense variety of patterns, from low-cellularity benign lesions such as lentigo simplex and benign melanocytic nevi, to atypical (dysplastic) melanocytic nevi, and finally to the malignant counterpart: melanoma.

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