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Management of Mucosal and Ocular Melanoma 

Management of Mucosal and Ocular Melanoma
Chapter:
Management of Mucosal and Ocular Melanoma
Author(s):

Alexander N. Shoushtari

and Richard D. Carvajal

DOI:
10.1093/med/9780199971015.003.0012
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date: 15 September 2019

Malignant melanomas account for 1–2% of all malignancies, with the vast majority of cases representing cutaneous primary tumors. In 5–10% of cases, however, melanoma arises from mucosal areas, the uveal tract of the eye, or an unknown primary site. Recently, advances in targeted kinase inhibitors and immune therapy have revolutionized the treatment of melanoma. These trials were largely conducted in cutaneous melanoma, however, and there are fewer published data regarding therapy in mucosal and ocular melanomas. Given the increasing knowledge of the distinct molecular changes underlying these various melanoma subtypes, it is increasingly important to understand the distinct epidemiology, presentation, prognosis, and treatment options for these subtypes.

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