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Management of Melanoma Brain Metastases 

Management of Melanoma Brain Metastases
Chapter:
Management of Melanoma Brain Metastases
Author(s):

Solmaz Sahebjam

, Nikhil G. Rao

, and Peter A. Forsyth

DOI:
10.1093/med/9780199971015.003.0011
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date: 23 September 2019

Melanoma commonly metastasizes to the brain and central nervous system (CNS); CNS metastases occur in more than half of patients with advanced melanoma. This remarkable neurotropism has not yet been explained. The prognosis of patients with melanoma brain metastasis remains grim, and the median overall survival after diagnosis of brain metastases is only two to nine months. This chapter asserts that the optimal management of melanoma brain metastasis patients requires the multidisciplinary collaboration of neurosurgeons, radiation oncologists, neuro-oncologists, and medical oncologists to tailor the treatment plan based on the clinical condition of the patient and the molecular characteristics of the tumor. Ideally this should be done in a dedicated melanoma brain metastases clinic. This chapter discusses each of the individual treatment modalities.

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