Show Summary Details
Page of

MSX2 in Craniosynostosis and Defects of Skull Ossification 

MSX2 in Craniosynostosis and Defects of Skull Ossification
MSX2 in Craniosynostosis and Defects of Skull Ossification

Mamoru Ishii

, Robert Maxson

, and Ulrich Muller

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 04 March 2021

Mutations in the homeobox gene MSX2 can result in both craniosynostosis (premature fusion of the calvarial sutures) and parietal foramina (PFM) (delayed ossification along the sagittal sutures). Msx2 has major roles in the growth of the mammalian skull vault and the development of the calvarial sutures. A gain-of-function mutation in MSX2 (Pro148His) results in craniosynostosis, while loss-of-function mutations of Msx2 result in PFM.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.