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PDX1, Pancreatic Agenesis, and Type 2 Diabetes 

PDX1, Pancreatic Agenesis, and Type 2 Diabetes
PDX1, Pancreatic Agenesis, and Type 2 Diabetes

Melissa K. Thomas

and Joel F. Habener

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date: 27 February 2021

Pancreas duodenum homeobox-1 (PDX-1) is a pancreas-specific homeodomain transcription factor that regulates embryonic pancreas development, the expression of genes essential for glucose metabolism, and the differentiation, survival, and function of insulin-producing cells in the endocrine pancreas. Expression of PDX-1 is confined primarily to the developing embryonic pancreas and the adult pancreatic β‎ cells, and PDX-1 function is essential for the proper development of both the endocrine and the exocrine pancreas and for normal metabolic function in the adult. Mutations in the PDX-1 gene are associated with multiple metabolic phenotypes in humans.

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