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STK11 (LKB1) and Peutz-Jeghers Syndrome 

STK11 (LKB1) and Peutz-Jeghers Syndrome
STK11 (LKB1) and Peutz-Jeghers Syndrome

Stylianos E. Antonarakis

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date: 04 March 2021

Peutz-Jeghers syndrome is an autosomal dominant syndrome of intestinal polyposis and mucocutaneous pigmentation changes. It is due to germ line or somatic mutations in STK11 and shows cancer susceptibility. Its oncogenic properties may be due to its effects on the mTOR pathway (Aube, et al, 2014).

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