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AMH/MIS and Its Receptors: The Persistent Müllerian Duct Syndrome 

AMH/MIS and Its Receptors: The Persistent Müllerian Duct Syndrome
Chapter:
AMH/MIS and Its Receptors: The Persistent Müllerian Duct Syndrome
Author(s):

Jean-Yves Picard

DOI:
10.1093/med/9780199934522.003.0051
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date: 24 February 2021

Antimüllerian hormone (AMH), also called müllerian inhibiting substance (MIS), is a member of the transforming growth factor-β‎ (TGF-β‎) family, produced exclusively by the gonads, that plays an important role in sex differentiation and gonadal function. Its action involves WNT inhibitory factor 1 (Wif2; Park, et al, 2014). Mutations in either the hormone or its receptor lead to persistent mullerian derivatives causing crpyptorchidism. Male sterility is frequent even when testes are lowered early.

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