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Development of Left-Right Asymmetry 

Development of Left-Right Asymmetry
Chapter:
Development of Left-Right Asymmetry
Author(s):

Hiroshi Hamada

DOI:
10.1093/med/9780199934522.003.0005
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date: 24 February 2021

Our body possesses three body axes, anteroposterior (A-P), dorsoventral (D-V), and left-right (L-R) axes. Among the three axes, the L-R axis is the last one to be established during development. L-R asymmetric morphogenesis is achieved by three consecutive steps: (1) The initial breaking of L-R symmetry, which occurs in or near the node and at the late neural-fold stage; (2) Transfer of an L-R–biased signal(s) from the node to the lateral plate mesoderm (LPM), which leads to L-R asymmetric expression of signaling molecules such as the transforming growth factor–β‎ (TGF-β‎)–related proteins Nodal and Lefty on the left side of the LPM; (3) L-R asymmetric morphogenesis of visceral organs induced by these signaling molecules. Here I describe the current understanding of the mechanism that generates L-R asymmetry in the mouse embryo.

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