Show Summary Details
Page of

Development of Left-Right Asymmetry 

Development of Left-Right Asymmetry
Development of Left-Right Asymmetry

Hiroshi Hamada

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 24 February 2021

Our body possesses three body axes, anteroposterior (A-P), dorsoventral (D-V), and left-right (L-R) axes. Among the three axes, the L-R axis is the last one to be established during development. L-R asymmetric morphogenesis is achieved by three consecutive steps: (1) The initial breaking of L-R symmetry, which occurs in or near the node and at the late neural-fold stage; (2) Transfer of an L-R–biased signal(s) from the node to the lateral plate mesoderm (LPM), which leads to L-R asymmetric expression of signaling molecules such as the transforming growth factor–β‎ (TGF-β‎)–related proteins Nodal and Lefty on the left side of the LPM; (3) L-R asymmetric morphogenesis of visceral organs induced by these signaling molecules. Here I describe the current understanding of the mechanism that generates L-R asymmetry in the mouse embryo.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.