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The Hedgehog Signaling Network* 

The Hedgehog Signaling Network*
Chapter:
The Hedgehog Signaling Network*
Author(s):

M. Michael Cohen

DOI:
10.1093/med/9780199934522.003.0027
Page of

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date: 09 March 2021

Topics discussed include overview of hedgehog signaling; mammalian hedgehog genes; lipid adducts attached to the hedgehog ligand; studies of the C-terminal cholesterol moiety; Patched 1, Patched 2, and Dispatched; sterol sensing domain; Smoothened; hedgehog signaling on the cilium; hedgehog signaling in vertebrates; cell surface and extracellular matrix proteins; hedgehog interacting protein (Hip 1) and growth arrest specific 1 (Gas 1); Rab23; GLI gene family; target genes; holoprosencephaly; nevoid basal cell carcinoma syndrome (Gorlin syndrome); and concluding comments

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