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Classic Lissencephaly 

Classic Lissencephaly
Classic Lissencephaly

Joseph G. Gleeson

and Deborah J. Morris Rosendahl

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date: 28 February 2021

Classical lissencephaly (LIS) is a neurodevelopmental disorder that affects approximately 1:40,000 individuals. It is characterized by the presence of a severely thickened cerebral cortical gray matter with widely spaced gyri and sulci. Diagnosis of LIS is made by the characteristic magnetic resonance imaging (MRI) appearance of the brain. Associated clinical features include significant mental retardation, intractable epilepsy, and shortened life expectancy.

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