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Development of Epidermal Appendages: Teeth and Hair 

Development of Epidermal Appendages: Teeth and Hair
Development of Epidermal Appendages: Teeth and Hair

Atsushi Ohazama

and Paul T. Sharpe

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date: 27 February 2021

The epidermis plays many critical roles in thermoregulation, protection, sensation, defense and social interaction. To fulfill these multiple functions, the epidermis can take many forms, known as epidermal appendages that include hair and teeth. Epidermal appendages initiate their formation by a common developmentally conserved pattern of inductive tissue interactions between ectodermal epithelium and mesenchyme. In the past decades, the production of transgenic mice with altered gene function has progressively discerned molecular mechanisms involved in epidermal appendage development. Here we review literature concerning molecular regulation in development of epidermal appendage, teeth and hair.

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