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Limb Development 

Limb Development
Limb Development

Malte Spielmann

and Sigmar Stricker

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date: 24 February 2021

The developing limb bud is one of the pivotal models for the elucidation of mechanisms orchestrating the formation of a complex organ system. Starting from surgical manipulation of model organisms and ranging to today’s molecular techniques, the limb bud was instrumental in shaping our understanding of three-dimensional patterning and tissue differentiation. Furthermore, the appendicular skeleton is frequently affected in human congenital anomaly syndromes that add a wealth of information. This chapter reviews our current understanding of the mechanisms involved in the induction, outgrowth, patterning and tissue differentiation in the vertebrate limb.

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