Show Summary Details
Page of

Muscle and Somite Development 

Muscle and Somite Development
Muscle and Somite Development

Douglas M. Anderson

and Alan Rawls

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 04 March 2021

The genetic pathways regulating skeletal muscle development are among the most intensely during the past 30 years. This is due in large part to cell culture systems that accurately recapitulate muscle differentiation and allow experimental manipulation of signals necessary for myogenesis. Further, the characterization of the myogenic regulatory factors (myf-5, MyoD, myogenin, and MRF4) that began in the late 1980’s provided the initial targets for to study the activation of muscle-specific gene expression. The lessons learned in the elucidation of the complex regulatory network that controls myoblast proliferation, differentiation, hypertrophy, atrophy, and fiber type specificity serve as a paradigm for vertebrate organogenesis. The development of skeletal muscle is intimately linked to somitogenesis. skeletal muscle progenitors first appear within individual somites derived from paraxial mesoderm. During embryonic development, these cells must undergo rapid expansion, migration, differentiation, and remodeling in order to generate the morphologically and functionally diverse perinatal muscles groups. Myogenic cells must also respond to spatial and temporal cues that lead to differences in cell fate along the anterior/posterior (A/P) and dorsal/ventral (D/V) axes. In this chapter we will review the embryonic development of somites and muscle and focus on our current understanding of the genetic regulation of somitogenesis and skeletal muscle development.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.