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Drug-Induced Movement Disorders 

Drug-Induced Movement Disorders
Chapter:
Drug-Induced Movement Disorders
Author(s):

Paul E. Greene

DOI:
10.1093/med/9780199925643.003.0010
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date: 18 April 2021

The most common drug-induced movement disorders are caused by drugs that affect dopamine transmission in the brain: either levodopa or centrally acting dopamine receptor blockers (DRBA). DRBA cause three distinct patterns of movement disorder: acute dystonic reaction, withdrawal emergent syndrome, and tardive syndromes. Tardive movements are difficult to treat but may improve with medications that interfere with dopamine by blocking the receptor or depleting dopamine from the brain. Levodopa can induce involuntary movements, either dyskinesias or dystonia, in patients with Parkinson’s disease. These movements may appear between levodopa doses, when dopamine levels in the brain are presumably at a maximum, or as the levodopa begins to take effect and as the effect begins to wane, called diphasic dyskinesias. Some medications can reduce dyskinesias without worsening parkinsonian symptoms. If that is not effective, deep brain stimulation often helps.

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