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Obesity and Asthma: Comorbid and Coexisting 

Obesity and Asthma: Comorbid and Coexisting
Chapter:
Obesity and Asthma: Comorbid and Coexisting
Author(s):

Erick Forno

, Louis-Philippe Boulet

, and Juan C. Celedón

DOI:
10.1093/med/9780199918065.003.0024
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date: 23 April 2021

The current epidemiologic and experimental evidence for a causal association between obesity and asthma is reviewed in this chapter. Putative mechanisms underlying the association between obesity and asthma, including genetics, changes in lung mechanics and airway smooth muscle physiology, hormonal differences, and detrimental effects of comorbidities and the systemic proinflammatory state of obesity are also discussed. These proposed causal pathways are largely speculative or insufficiently studied. Whereas obesity seems to be closely interrelated with the pathogenesis of asthma in some subjects who have the true “obese asthmatic phenotype,” obesity may simply coexist with asthma in others. Proper identification of subjects with true “obese asthma” may be key to dissecting any causal mechanism. Weight loss is beneficial and should be recommended for obese adults with asthma.

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