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Nasal Polyps and Chronic Rhinosinusitis: Comorbid 

Nasal Polyps and Chronic Rhinosinusitis: Comorbid
Nasal Polyps and Chronic Rhinosinusitis: Comorbid

Hae-Sim Park

, Mario Sánchez-Borges

, Seung Youp Shin

, and Marek L. Kowalski

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date: 09 May 2021

Chronic rhinosinusitis (CRS) and nasal polyp (NP) are major comorbid conditions of bronchial asthma. CRS with NP (CRSwNP) occurs in the setting of CRS characterized by TH2 and eosinophilic inflammation. Therefore, CRSwNP is considered an entity separate from CRS without NP (CRSsNP). Previous studies demonstrated a strong association between asthma and CRS, and patients with asthma and CRS are more likely to have NP. The presence of CRSwNP can increase asthma severity, and effective medical management can improve asthma outcomes, including overall lung function and asthma control, and drug requirements. Surgery should be reserved for select patients with inadequate response to medical management or medication intolerance or side effects. Future research may further elucidate the pathophysiology of CRS and NP, which may in turn lead to development of more effective treatment modalities.

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