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Hypersensitivity Pneumonitis: Coexisting and Differential Diagnosis 

Hypersensitivity Pneumonitis: Coexisting and Differential Diagnosis
Hypersensitivity Pneumonitis: Coexisting and Differential Diagnosis

David I. Bernstein

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date: 05 May 2021

Hypersensitivity pneumonitis (HP), also referred to as extrinsic allergic alveolitis, is an allergic inflammatory parenchymal lung disease usually caused by inhalational exposure to organic antigens from microbial bioaerosols or animal sources encountered in the work or home environment. Patients with HP can present with wheezing and obstructive abnormalities leading to an incorrect asthma diagnosis. The presence of a gas exchange abnormality, bronchoalveolar lavage lymphocytosis, and characteristic infiltrative changes on high-resolution computed tomography of the chest can be used to distinguish HP from asthma. The early diagnosis of HP and cessation of exposure to causative antigens result in remission of the disease and no residual impairment.

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