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Psychoneuroimmunology in Dermatology 

Psychoneuroimmunology in Dermatology
Psychoneuroimmunology in Dermatology

Kristopher Denby

, Nana Duffy

, and Francisco Tausk

Page of

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date: 27 January 2021

Psychoneuroimmunology (PNI) examines the relationship between the central nervous system (CNS) and the immune system. Psychological stressors have the potential to alter immune reactions, and chronicity of the stressor is a major contributing factor. Studies have demonstrated a negative impact of a variety of psychological stressors on wound healing, in terms of duration as well as complication.Stress and anxiety have been shown to increase the perception of itch in atopic dermatitis, with positive benefits of anxiolytic therapy.Stress-reduction techniques such as hypnosis, guided imagery, and mindfulness based stress reduction can have a significant positive impact on psoriasis.Stress-mediated release of pro-inflammatory cytokines may be the underlying explanation for histopathologic findings in chronic urticaria, and may also suggest stress reduction as an adjunctive treatment option.Animal models show that stress plays a role in tumorigenesis and metastasis, suggesting a potential link between stress and skin cancer.

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