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New Drug Development, Drug Response, and Precision Medicines 

New Drug Development, Drug Response, and Precision Medicines
Chapter:
New Drug Development, Drug Response, and Precision Medicines
Author(s):

Michelle Penny

and Duncan McHale

DOI:
10.1093/med/9780199896028.003.0008
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date: 06 June 2020

During the last the pharmaceuticals industry producing many highly effective new classes of drugs from statins to proton-pump inhibitors and quinolone antibiotics. All were novel therapeutic approaches offering significant benefit to individuals and society. The science that drove many of these advances was based on the greater understanding of biochemistry and pharmacology that emerged during the 1970s and early 1980s. This ten to fifteen years time lag from gaining scientific knowledge to developing therapies is typical for the pharmaceutical industry, and reflects the complexity of drug discovery and the time required for preclinical and clinical testing to ensure safety and efficacy. This chapter introduces the major concepts of new drug discovery and development and give a broad overview of how genetics and genomics is harnessed across the whole drug discovery and development pipeline, from pre-target identification to post-marketing surveillance to help discover and develop improved medicines.

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