Contents

Disclaimer

Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages and recommendations are for the non-pregnant adult who is not breastfeeding.

Show Summary Details
Page of

Genomic Perspectives of Clinical Immunology 

Genomic Perspectives of Clinical Immunology
Chapter:
Genomic Perspectives of Clinical Immunology
Author(s):

Cornelius L. Verweij

DOI:
10.1093/med/9780199896028.003.0038
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 29 May 2020

Recent advances and new developments in genomics research provide the opportunity to characterize many new genes with unknown function, hitherto uncharacterized previously unknown genes and many genomic variants to be involved in complex biological processes such as in immunology. Besides a more detailed understanding in basic processes in immunology, microarray studies have increased our insight in the immunological mechanisms that contribute to chronic immune-related diseases. Of particular interest is the overlap of genes identified in these diseases with genes that are induced in response to a microbial stimulus. Moreover, genome-wide studies have provided evidence for the existence of genetically determined differences in immune activity that might have consequences for susceptibility and/or outcome of immune-related diseases. Large scale gene-expression and genome-wide analysis is of great relevance in the field of immunology to generate a global view of how the immune systems attacks invading microorganisms, maintains tolerance, or creates a memory for past infections. The exciting part of microarray studies is that the many data points that are generated give rise to unpredictable and unexpected results, which may lead to new insights in immunology.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.