Show Summary Details
Page of

Genetics and Genomics of Neuro-Psychiatric Diseases, I: Seizure Disorders 

Genetics and Genomics of Neuro-Psychiatric Diseases, I: Seizure Disorders
Genetics and Genomics of Neuro-Psychiatric Diseases, I: Seizure Disorders

William Owen Pickrell

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 25 January 2021

Epilepsy, one of the most common neurological disorders, is estimated to affect around 1% of all populations, probably higher in resource poor areas, and at least 50 million people are affected worldwide. There is a clear link between genetics and epilepsy - 1st degree relatives of people with epilepsy are around two to four times more likely to develop epilepsy than the general population and monozygotic twins show a higher rate of concordance when compared to dizygotic twins. More than 100 years ago, the inherited influence was suggested in around 31%, remarkably similar to the estimate that is widely used today - genetic factors account for around 40% of all epilepsies. It is only during the last 15 years or so that real progress has been made into understanding some of the complicated genetics involved with epilepsy. The ability to use powerful new genomic technology marks an exciting time, promising to yield further significant advances in our understanding, with the ultimate aim to improve the treatment and quality of life of people with the disease. The classification of seizures and epilepsy includes a number of predominantly monogenic genetic and symptomatic complex epilepsies. In addition, some aspects of contemporary epilepsy treatment are influenced by genomics.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.