- 19. Genetic and Genomic Approaches to Clinical Medicine
- 20. Genetic and Genomic Taxonomy of Human Disease
- 21. Genomics of Complex Cardiovascular Disease
- 22. Genomics of Type 2 Diabetes Mellitus and Obesity
- 23. Genetics and Genomics of Osteoporosis and Related Disorders
- 24. Genetics and Genomics of Chronic Kidney Disease
- 25. Genetics and Genomics in Clinical Hematology, I: Hemostasis and Thrombosis
- 26. Genetics and Genomics in Clinical Hematology, II: Inherited Disorders of Hemoglobin
- 27. Genetic and Genomics in Clinical Hematology, III: Acute Leukemias
- 28. Genetics and Genomics of Chronic Inflammatory Disorders, I: Inflammatory Bowel Disease
- 29. Genetics and Genomics of Chronic Inflammatory Disorders, II: Rheumatoid Arthritis and Related Arthropathies
- 30. Genetics and Genomics of Chronic Inflammatory Disorders, III: Bronchial Asthma
- 31. Genetics and Genomics of Neuro-Psychiatric Diseases, I: Seizure Disorders
- 32. Genetics and Genomics of Neuro-Psychiatric Diseases, II: Multiple Sclerosis
- 33. Genetics and Genomics of Neuro-Psychiatric Diseases, III: The Common Dementias
- 34. Genetics and Genomics of Neuro-Psychiatric Diseases, IV: Schizophrenia and Bipolar Disorder
- 35. Genetics and Genomics of Neuro-Psychiatric Diseases, V: Learning and Behavioral Disorders
- 36. Clinical Cancer Genomics
- 37. Genomics and Infectious Diseases: Susceptibility, Resistance, Response, and Antimicrobial Therapy
- 38. Genomic Perspectives of Clinical Immunology
- 39. Genomic Applications in Clinical Pediatrics
- 40. Genetics and Genomics in Clinical Ophthalmology, I: The Spectrum of Genetic Eye Disease
- 41. Genetics and Genomics in Clinical Ophthalmology, II: Glaucoma
- 42. Genetics and Genomics in Clinical Ophthalmology, III: Age-Related Macular Degeneration
- 43. Genomic Applications in Audiological Medicine
- 44. Genetics and Genomics of Skin Diseases I: Atopic Dermatitis and Other Skin Complex Diseases
- 45. Genetics and Genomics of Skin Diseases, II: Genomics of Pigmentation and Skin Cancer
- 46. The Genetic and Genomic Practice of Reproductive Medicine
- 47. Stem Cell Genomics: Developmental Competence
- 48. Genomic Applications in Critical Care Medicine
- 49. Molecularly Targeted Therapy for Mendelian Disorders
- 50. Glossary for Genetic and Genomic Medicine<sup>*</sup>
(p. 473) Genetics and Genomics of Neuro-Psychiatric Diseases, I: Seizure Disorders
- Chapter:
- (p. 473) Genetics and Genomics of Neuro-Psychiatric Diseases, I: Seizure Disorders
- Author(s):
William Owen Pickrell
- DOI:
- 10.1093/med/9780199896028.003.0031
Epilepsy, one of the most common neurological disorders, is estimated to affect around 1% of all populations, probably higher in resource poor areas, and at least 50 million people are affected worldwide. There is a clear link between genetics and epilepsy - 1st degree relatives of people with epilepsy are around two to four times more likely to develop epilepsy than the general population and monozygotic twins show a higher rate of concordance when compared to dizygotic twins. More than 100 years ago, the inherited influence was suggested in around 31%, remarkably similar to the estimate that is widely used today - genetic factors account for around 40% of all epilepsies. It is only during the last 15 years or so that real progress has been made into understanding some of the complicated genetics involved with epilepsy. The ability to use powerful new genomic technology marks an exciting time, promising to yield further significant advances in our understanding, with the ultimate aim to improve the treatment and quality of life of people with the disease. The classification of seizures and epilepsy includes a number of predominantly monogenic genetic and symptomatic complex epilepsies. In addition, some aspects of contemporary epilepsy treatment are influenced by genomics.
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- 19. Genetic and Genomic Approaches to Clinical Medicine
- 20. Genetic and Genomic Taxonomy of Human Disease
- 21. Genomics of Complex Cardiovascular Disease
- 22. Genomics of Type 2 Diabetes Mellitus and Obesity
- 23. Genetics and Genomics of Osteoporosis and Related Disorders
- 24. Genetics and Genomics of Chronic Kidney Disease
- 25. Genetics and Genomics in Clinical Hematology, I: Hemostasis and Thrombosis
- 26. Genetics and Genomics in Clinical Hematology, II: Inherited Disorders of Hemoglobin
- 27. Genetic and Genomics in Clinical Hematology, III: Acute Leukemias
- 28. Genetics and Genomics of Chronic Inflammatory Disorders, I: Inflammatory Bowel Disease
- 29. Genetics and Genomics of Chronic Inflammatory Disorders, II: Rheumatoid Arthritis and Related Arthropathies
- 30. Genetics and Genomics of Chronic Inflammatory Disorders, III: Bronchial Asthma
- 31. Genetics and Genomics of Neuro-Psychiatric Diseases, I: Seizure Disorders
- 32. Genetics and Genomics of Neuro-Psychiatric Diseases, II: Multiple Sclerosis
- 33. Genetics and Genomics of Neuro-Psychiatric Diseases, III: The Common Dementias
- 34. Genetics and Genomics of Neuro-Psychiatric Diseases, IV: Schizophrenia and Bipolar Disorder
- 35. Genetics and Genomics of Neuro-Psychiatric Diseases, V: Learning and Behavioral Disorders
- 36. Clinical Cancer Genomics
- 37. Genomics and Infectious Diseases: Susceptibility, Resistance, Response, and Antimicrobial Therapy
- 38. Genomic Perspectives of Clinical Immunology
- 39. Genomic Applications in Clinical Pediatrics
- 40. Genetics and Genomics in Clinical Ophthalmology, I: The Spectrum of Genetic Eye Disease
- 41. Genetics and Genomics in Clinical Ophthalmology, II: Glaucoma
- 42. Genetics and Genomics in Clinical Ophthalmology, III: Age-Related Macular Degeneration
- 43. Genomic Applications in Audiological Medicine
- 44. Genetics and Genomics of Skin Diseases I: Atopic Dermatitis and Other Skin Complex Diseases
- 45. Genetics and Genomics of Skin Diseases, II: Genomics of Pigmentation and Skin Cancer
- 46. The Genetic and Genomic Practice of Reproductive Medicine
- 47. Stem Cell Genomics: Developmental Competence
- 48. Genomic Applications in Critical Care Medicine
- 49. Molecularly Targeted Therapy for Mendelian Disorders
- 50. Glossary for Genetic and Genomic Medicine<sup>*</sup>