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Genetics and Genomics of Chronic Kidney Disease 

Genetics and Genomics of Chronic Kidney Disease
Chapter:
Genetics and Genomics of Chronic Kidney Disease
Author(s):

Albert C. M. Ong

and Alexander P. Maxwell

DOI:
10.1093/med/9780199896028.003.0024
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date: 07 June 2020

Chronic renal diseases are heterogeneous and collectively a huge burden on medical and socio-economic resources. The prevalence of end-stage renal disease (ESRD) is steadily increasing contributing to growth in provision of renal replacement therapy (dialysis and transplantation) for over one million individuals worldwide. Living with ESRD is challenging for individuals and the economic costs of renal replacement therapy for society are enormous. There is increasing evidence for genetic (polygenic) susceptibility for diabetic nephropathy. Autosomal dominant polycystic kidney disease (ADPKD) accounts for 5-10% of prevalent ESRD and is the single most common monogenic cause of chronic renal disease. Heterogeneous genetic factors can modify the phenotypic expression of these two common chronic diseases and illustrate the different experimental approaches that are being used to identify modifying genes important in chronic kidney disease.

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