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Anesthetic Neurotoxicity: Effects of Anesthetic Drugs on the Developing Brain 

Anesthetic Neurotoxicity: Effects of Anesthetic Drugs on the Developing Brain
Chapter:
Anesthetic Neurotoxicity: Effects of Anesthetic Drugs on the Developing Brain
Author(s):

Ansgar M. Brambrink

DOI:
10.1093/med/9780199895724.003.0001
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date: 22 February 2020

“Chapter 1 discusses the mounting experimental evidence that suggests sedatives and anesthetics have toxic effects on the developing brain, causing long-term neurobehavioral impairment and permanent neuropathologic changes in animals exposed to these drugs in the first weeks of their life. It also covers the retrospective data analysis that points to an association between exposure to anesthesia at a young age (<3 years of age) and neurobehavioral disturbances during later development, while allowing that the same data do not allow us to determine whether this is a causal relationship, and how it is imperative to conduct well-designed human trials to determine the clinical risk as well as the key confounding variables.”

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