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A Circular Conundrum: Sleep Disruption Worsens Pain and Pain Medications Disrupt Sleep 

A Circular Conundrum: Sleep Disruption Worsens Pain and Pain Medications Disrupt Sleep
Chapter:
A Circular Conundrum: Sleep Disruption Worsens Pain and Pain Medications Disrupt Sleep
Author(s):

Michael Sternberg

, Helen A. Baghdoyan

, and Ralph Lydic

DOI:
10.1093/med/9780199859436.003.0007
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date: 21 April 2021

Pain is worsened by sleep disruption. Objective, polysomnographic recordings of sleep and wakefulness show that sleep is disrupted by every pain medication studied. The brain circuits and neurochemical mechanisms by which pain medications alter sleep remain poorly understood. This chapter selectively highlights sleep-altering effects associated with the four major classes of pain medication. The chapter emphasizes gaps in knowledge as opportunities for translational research. Facilitating the interface between sleep neurobiology and pain medicine can significantly contribute to improved patient care.

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