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NSAIDs and Adjunctive Pain Medications 

NSAIDs and Adjunctive Pain Medications
NSAIDs and Adjunctive Pain Medications

Howard S. Smith

, Kalyna Apkarian

, and Charles E. Argoff

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date: 21 April 2021

Collectively, NSAIDs and acetaminophen are the most commonly used pain medications. NSAIDs differ from acetaminophen in that they are slightly more efficacious, possess anti-inflammatory properties, and are associated with a different side effect profile, to include bleeding, gastrointestinal ulceration, renal dysfunction, and an elevated risk of adverse cardiovascular events. First-line treatments for neuropathic pain are typically gabapentinoid drugs and tricyclic antidepressants, though other medications may be employed in different contexts. In this chapter, a variety of different types of NSAIDs and adjuvants are discussed, to include their indications, effectiveness for various conditions, combination treatment, and side effects and contraindications.

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