Show Summary Details
Page of

Central Pain Syndromes 

Central Pain Syndromes
Chapter:
Central Pain Syndromes
Author(s):

Brian G. Wilhelmi

and Srinivasa N. Raja

DOI:
10.1093/med/9780199859436.003.0019
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 21 April 2021

Central Pain Syndrome is a painful constellation of symptoms and signs initiated or caused by a primary lesion or disease affecting the central nervous system. Central pain may be associated with heterogeneous etiologies that result in pathophysiologic changes in the brain and/or spinal cord. These pathologies of the central nervous system are hypothesized to result in increased activation of excitatory neuronal systems or “pain generator” pathways as well as decreased neuronal inhibition that leads to “disinhibition” of pain regulatory pathways. Although diverse in nature and presentation, common themes emerge in the pathophysiology and treatment of central pain states. A multi-modal strategy of psychological, physical, pharmacologic, and surgical treatments is utilized as the physician partners with the patient through therapeutic trials directed at developing optimal treatment plans.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.