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Herpes Zoster and Postherpetic Neuralgia 

Herpes Zoster and Postherpetic Neuralgia
Herpes Zoster and Postherpetic Neuralgia

Julie H. Y. Huang

, Andrei D. Sdrulla

, and Mark Wallace

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date: 21 April 2021

Postherpetic neuralgia (PHN) is a neuropathic pain condition that develops in approximately 15% of individuals with herpes zoster infection. The disease most commonly occurs as a result of an age-related decline in cell-mediated immunity. The pathophysiology encompasses both peripheral and central mechanisms, and treatment options include pharmacological and interventional modalities, as well as primary prevention of herpes zoster and PHN through vaccination and/or the use of anti-viral agents. The effectiveness of these different treatment modalities, to include medications and procedural interventions, are reviewed in this chapter.

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