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Integration and Consolidation: A Neurophysiological Model of Bipolar Disorder 

Integration and Consolidation: A Neurophysiological Model of Bipolar Disorder
Integration and Consolidation: A Neurophysiological Model of Bipolar Disorder

Stephen M. Strakowski

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date: 23 June 2021

Bipolar disorder is one of the most common and disabling conditions affecting humankind. Although defined by the occurrence of mania, it is characterized by a dynamic course of illness in which affective, cognitive and neurovegetative symptoms wax and wane. The illness typically starts in adolescence and progresses during its early years from rare to increasingly common affective episodes. Bipolar disorder is strongly familial, suggesting that it originates from specific genetic risk factors, although these have not yet been well defined. Together, these characteristics suggest that bipolar disorder involves dysfunction within ventral prefrontal networks that modulate limbic brain structures. Moreover, this dysfunction appears to arise during critical developmental stages in brain development, likely reflecting the impact of specific genes that underlie brain growth and development, monamine control, circadian rhythm regulation or related functions. In this chapter, then, we converge evidence from neuroimaging and genetic studies to develop a specific neurophysiological model of bipolar disorder to guide future investigations.

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