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Integrating Imaging and Genetic Research: Toward Personalized Medicine 

Integrating Imaging and Genetic Research: Toward Personalized Medicine
Chapter:
Integrating Imaging and Genetic Research: Toward Personalized Medicine
Author(s):

Roy H. Perlis

and Hilary P. Blumberg

DOI:
10.1093/med/9780199797608.003.0101
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date: 13 October 2019

Neuroimaging studies demonstrate a convergence of findings in showing abnormalities in a corticolimbic system including the ventral prefrontal and anterior cingulate cortices and amygdala, their limbic, striatothalamic and cerebellar connections sites, and in the structure and function of the connections. Genetic association studies likewise have begun to implicate common variation in genes that may moderate development, plasticity and functioning of the corticolimbic system. This chapter reviews combined imaging and genetics studies of bipolar disorder that hold promise for further elucidating the molecular mechanisms that contribute to the brain changes of bipolar disorder. In addition to considering their direct implications for understanding the pathophysiology of this illness, the chapter addresses how such studies may inform future investigations by establishing more homogeneous patient populations. Finally, it takes an even broader perspective and considers the point at which such integrated studies may be directly applied to guide clinical practice and personalized treatment.

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