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Genetic Techniques and Their Application to Bipolar Disorder 

Genetic Techniques and Their Application to Bipolar Disorder
Genetic Techniques and Their Application to Bipolar Disorder

Aaron C. Vederman

and Melvin G. McInnis

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date: 29 July 2021

The last decade has witnessed a dramatic increase in the advancement and use of genetic technique to investigate the potential causes and treatment targets for a variety of medical conditions. Bipolar disorder is strongly familial, with very high heritability rates, making it an ideal candidate for genetic investigations. This chapter discusses some of the recent advances in these techniques and provides examples of use in bipolar disorder to provide context for additional genetics discussions in this book. In particular, this chapter outlines how these techniques let away from single genes as comprehensive risks for bipolar disorder to broader models that consider additive effects of small risks from multiple genetic variants. The chapter also examines epigenetic approaches to studying bipolar illness and how these approaches might complement standard genetic techniques. Other more specialized approaches including functional genetics and pharmacogenetics are considered. The chapter ends by integrating these discussions into consideration of a systems biology approach to complex conditions like bipolar disorder.

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