Show Summary Details
Page of

Neurochemical and Metabolic Imaging in Bipolar Disorder 

Neurochemical and Metabolic Imaging in Bipolar Disorder
Neurochemical and Metabolic Imaging in Bipolar Disorder

Jieun E. Kim

, In Kyoon Lyoo

, and Perry F. Renshaw

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 29 July 2021

Magnetic resonance spectroscopy (MRS) is an important neuroimaging technique offering the promise of revolutionizing how we study human brain function by allowing the examination of molecular processes in the live human brain. This chapter reviews both proton (1H) and phosphorus (31P) MRS studies in bipolar disorder and proposes a neurochemical model of this illness. Integration of the MRS findings including alterations in cerebral levels of N-acetyl aspartate, glutamate/glutamine, choline-containing compounds, myo-inositol, and lactate, measured using 1H MRS and alterations in cerebral levels of phosphocreatine, phosphomonoesters, and intracellular pH, measured using 31P MRS, leads to a well-supported hypothesis of an underlying mitochondrial impairment in bipolar disorder.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.