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Functional Brain Imaging in Bipolar Disorder 

Functional Brain Imaging in Bipolar Disorder
Chapter:
Functional Brain Imaging in Bipolar Disorder
Author(s):

Lori L. Altshuler

and Jennifer D. Townsend

DOI:
10.1093/med/9780199797608.003.0032
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date: 25 August 2019

The prefrontal cortex (PFC) integrates and regulates emotional responses. Diminished subcortical and limbic modulation and frontolimbic abnormities may represent substrates for the acute mood episode characteristic of bipolar disorder (BP).

This chapter will review fMRI studies performed in subjects with bipolar disorder during manic, depressive or euthymic states. Paradigms using tasks that probe emotion processing, emotion regulation, executive function, working memory and response inhibition have been used to assess activation in specific brain regions. Some abnormalities appear to be state related while others may represent enduring trait deficits.

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