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Bipolar Disorder 

Bipolar Disorder
Bipolar Disorder

Robert C. Young

and Nahla A. Mahgoub

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date: 17 October 2021

Older adults with bipolar (BP)disorder present a heterogeneous group of patients who have diverse clinical characteristics, and comorbidities and presumably differing pathophysiology and etiology. Age-related factors including age at onset of illness and age-associated neurobiological and psychosocial factors may contribute to these extents of heterogeneity. Relevant neurobiological changes may include vascular and degenerative processes. This chapter provides an overview of the limited evidence base. Investigation of this subgroup of BP patients presents both challengers and important opportunities for investigation. Opportunities include studies of markers of vulnerability, of how heterogeneity may be associated with differences in outcomes and may guide development of novel treatments, and of the nature of clinical features shared with other geriatric disorders.

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