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Integration of Biological, Clinical, and Psychosocial Predictors of Treatment Response Variability in Late-Life Depression 

Integration of Biological, Clinical, and Psychosocial Predictors of Treatment Response Variability in Late-Life Depression
Chapter:
Integration of Biological, Clinical, and Psychosocial Predictors of Treatment Response Variability in Late-Life Depression
Author(s):

Linda Garand

, Ellen M. Whyte

, Meryl A. Butters

, Elizabeth R. Skidmore

, Jordan F. Karp

, and Mary Amanda Dew

DOI:
10.1093/med/9780199796816.003.0042
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date: 01 December 2020

Progress has been made in delineating factors that contribute to treatment response variability in late life depression, yet large gaps remain in the literature. Much of the scientific effort to date has focused on understanding factors’ individual rather than combined effects. Within studies of individual effects, the emphasis has been on the impact of biological and clinical factors on the magnitude and speed of late-life treatment response. Less attention has been given to the role of intrapersonal and environmental factors in treatment outcomes. Although durability of response has less often been the focus of research than magnitude and speed of initial response, the same pattern of emphasis on biological and clinical factors appears, with considerably less information on intrapersonal and environmental influences on patient outcomes.

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