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Cognitive Biomarkers in Depression 

Cognitive Biomarkers in Depression
Chapter:
Cognitive Biomarkers in Depression
Author(s):

Oliver J. Robinson

and Barbara J. Sahakian

DOI:
10.1093/med/9780199796816.003.0035
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date: 19 February 2020

This chapter provides an overview of the altered cognitive performance in depression and discusses how measuring this impairment using neurocognitive tasks can reveal cognitive biomarkers. The difference between state biomarkers (which may aid in the treatment of disorders) and trait biomarkers (which may detect risk for disorders prior to their onset) is discussed, and the distinct effects of late-life depression on biomarkers are examined. The putative underlying causes of the biomarkers are then examined via functional imaging, models in healthy individuals, and genetic studies. The effects of treatment on biomarkers are discussed before concluding by emphasizing the possibility of using cognitive biomarkers to promote resilience in younger people and hence prevent the onset of late-life depression.

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