Show Summary Details
Page of

Cognitive Biomarkers in Depression 

Cognitive Biomarkers in Depression
Cognitive Biomarkers in Depression

Oliver J. Robinson

and Barbara J. Sahakian

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 21 October 2021

This chapter provides an overview of the altered cognitive performance in depression and discusses how measuring this impairment using neurocognitive tasks can reveal cognitive biomarkers. The difference between state biomarkers (which may aid in the treatment of disorders) and trait biomarkers (which may detect risk for disorders prior to their onset) is discussed, and the distinct effects of late-life depression on biomarkers are examined. The putative underlying causes of the biomarkers are then examined via functional imaging, models in healthy individuals, and genetic studies. The effects of treatment on biomarkers are discussed before concluding by emphasizing the possibility of using cognitive biomarkers to promote resilience in younger people and hence prevent the onset of late-life depression.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.