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Functional Neuroimaging in Late-Life Mood Disorders 

Functional Neuroimaging in Late-Life Mood Disorders
Functional Neuroimaging in Late-Life Mood Disorders

Meenal J. Patel

, Howard J. Aizenstein

, and Gwenn S. Smith

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date: 08 December 2021

Structural and functional neuroimaging modalities have identified changes in neural circuitries in patients with mood disorders in late life, including major depression and bipolar disorder. The most widely used imaging modalities include functional magnetic resonance imaging (fMRI) and positron emission tomography (PET). The major findings will be reviewed regarding the functional neuroanatomy of late life depression, changes in neural circuitry under conditions of affective and cognitive activation, changes in neural circuitry associated with antidepressant treatment, and molecular imaging studies of specific neurochemical markers and neuropathology. The potential for the neuroimaging measure to serve as neurobiological markers of treatment response, as well as future directions for fMRI and PET imaging, are discussed.

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