Show Summary Details
Page of

Structural Neuroimaging in Late-Life Mood Disorders 

Structural Neuroimaging in Late-Life Mood Disorders
Structural Neuroimaging in Late-Life Mood Disorders

Sean J. Colloby

and John T. O’Brien

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 23 October 2021

Affective disorder research has mainly focussed on studying many of the structures implicated within the limbic-cortical-striatal-pallidal-thalamic circuit. This chapter concentrates on structural MRI brain changes associated with unipolar major depression and bipolar disorder (BD) of late-life, with particular attention to structural imaging, white matter hyperintensities (WMH) and diffusion tensor imaging (DTI). Structural brain deficits are associated with LLD and LLBD, with a pattern supporting the notion of ‘frontostriatal’ disturbances in affective disorders of late-life. Increased prevalence of WMH is another characteristic of LLD and LLBD, with perhaps location rather than burden being more important to their pathogeneses, but may also indicate their increased cerebrovascular risk factors. Microstructural DTI changes are largely in frontal regions in LLD but in LLBD have not been investigated. Future studies with larger clinically representative populations with further aid to elucidate the specific anatomy and aetiology of structural MRI changes in late-life mood disorders and investigate their relationship with clinical factors.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.