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Depression Medication Treatment Adherence in Later Life 

Depression Medication Treatment Adherence in Later Life
Depression Medication Treatment Adherence in Later Life

Kara Zivin

, Janet Kavanagh

, Susan Maixner

, Jo Anne Sirey

, and Helen C. Kales

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date: 27 September 2021

While depression in older adults has been detected, diagnosed, and treated more frequently in recent years, substantial gaps in effective treatment remain. Improving adherence to depression treatment can be viewed as the “next frontier” in the treatment of late-life depression. In this chapter, we conceptualize and review the current evidence for key patient-level factors associated with depression treatment adherence among older adults. Factors are categorized according to whether their potential for impact on adherence might be influenced by specialized treatment approaches or interventions, as: 1) modifiable; 2) potentially modifiable; and 3) non-modifiable. A number of these factors are illustrated by a real-world clinical case. Finally, we discuss developing effective interventions to improve adherence to depression treatment in older adults.

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