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Depression in Dementia 

Depression in Dementia
Depression in Dementia

Christopher M. Marano

, Paul B. Rosenberg

, and Constantine G. Lyketsos

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date: 22 October 2021

Depression is among the most common and troubling neuropsychiatric symptoms of dementia. It is important to diagnose and treat depression in dementia given its substantial adverse effects on patient and caregiver quality of life. The symptoms of depression in dementia often differ from those of a typical major depressive episode seen in younger adults. As the most common cause of dementia and the subject of the vast majority of dementia research, the chapter focuses on depression in Alzheimer’s dementia (AD) as a prototype for the evaluation and management of depression in dementia. We briefly review the epidemiology and non-cognitive manifestations of AD and then discuss current evidence regarding the presentation, etiology, diagnosis, and treatment of depression in AD.

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