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Insensitivity to Pain: Lessons from Recent Genetics Advances 

Insensitivity to Pain: Lessons from Recent Genetics Advances
Insensitivity to Pain: Lessons from Recent Genetics Advances

Nancy Merner

, Patrick A. Dion

, Anna Szuto

, and Guy A. Rouleau

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date: 03 August 2021

Inherited peripheral neuropathies are clinically and genetically heterogeneous with over 30 causative genes associated to these disorders. The present chapter will not discuss all of these neuropathies; it will address only those that have been associated primarily with nociception defects and relative degrees of autonomic dysfunction for which a causative gene has been identified. Nociception, the ability to feel pain following the stimulation of a sensory receptor, is physiologically a four-step process: transduction, transmission, modulation, and perception.

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