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Edward C. Rosenow

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date: 18 April 2021

Metabolic disorder of deforming arthropathy

Homogentisic acid in urine, which becomes dark on standing and is characteristic

May be first diagnosed on lateral CXR

Eventually pigmentation of skin, sclerae, and ear and nose cartilage

Earliest change is laminated calcification of intervertebral disk, followed by collapse of disk spaces and osteoporosis. Osteophytes are a later occurrence, as is involvement of weight-bearing joints...

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