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Mecp2 Knockout in Mouse Models of Rett Syndrome 

Mecp2 Knockout in Mouse Models of Rett Syndrome
Chapter:
Mecp2 Knockout in Mouse Models of Rett Syndrome
Author(s):

Megumi Adachi

and Lisa M. Monteggia

DOI:
10.1093/med/9780199744312.003.0006
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date: 23 January 2021

Chapter 6 reviews the phenotypes of the constitutive Mecp2 KO mutant mice, those generated by expressing RTT -causing mutations, and conditional Mecp2 KO mice in comparison to clinical phenotypes presented in patients with RTT. It also covers therapeutic approaches currently reported using these RTT -model mice.

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