- Dedication
- Contributors
- 1 Introduction
- 2 Autism and Autism Spectrum Disorders: Clinical Overview
- 3 Neuroimaging in Autism Spectrum Disorders
- 4 An Overview of the Genetics of Autism Spectrum Disorders
- 5 Rett Syndrome: On Clinical and Genetic Features, and Experimental Models Based on MeCP2 Dysfunction
- 6 <i>Mecp2</i> Knockout in Mouse Models of Rett Syndrome
- 7 Putting Into Perspective the Use of the Fmr1 Knockout Mouse as a Model for Autism Spectrum Disorder
- 8 Molecular Functions of the Mammalian Fragile X Mental Retardation Protein: Insights Into Mental Retardation and Synaptic Plasticity
- 9 Tuberous Sclerosis and Autism
- 10 <i>PTEN</i> and Autism With Macrocepaly
- 11 <i>SHANK</i> Gene Family and Autism
- 12 Smith-Lemli-Opitz Syndrome and Role of Cholesterol in Autism
- 13 Angelman Syndrome
- 14 Neuroligins and Neurexins: Bridging the Synaptic Cleft in Autism
- 15 Alterations of the Serotonin–Melatonin Pathway in Autism Spectrum Disorders: Biological Evidence and Clinical Consequences
- 16 <i>CNTNAP2</i> and Autism Spectrum Disorders
- 17 Chromosome 15q11.2q13.3 Aneusomies and Autism Spectrum Disorders
- 18 Oxytocin and Vasopressin: Mechanisms for Potential Sex Differences Observed in Autism Spectrum Disorders
- 19 FOXP2: Linking Language and Autism
- Index
(p. 91) Mecp2 Knockout in Mouse Models of Rett Syndrome
- Chapter:
- (p. 91) Mecp2 Knockout in Mouse Models of Rett Syndrome
- Author(s):
Megumi Adachi
and Lisa M. Monteggia
- DOI:
- 10.1093/med/9780199744312.003.0006
Chapter 6 reviews the phenotypes of the constitutive Mecp2 KO mutant mice, those generated by expressing RTT -causing mutations, and conditional Mecp2 KO mice in comparison to clinical phenotypes presented in patients with RTT. It also covers therapeutic approaches currently reported using these RTT -model mice.
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- Dedication
- Contributors
- 1 Introduction
- 2 Autism and Autism Spectrum Disorders: Clinical Overview
- 3 Neuroimaging in Autism Spectrum Disorders
- 4 An Overview of the Genetics of Autism Spectrum Disorders
- 5 Rett Syndrome: On Clinical and Genetic Features, and Experimental Models Based on MeCP2 Dysfunction
- 6 <i>Mecp2</i> Knockout in Mouse Models of Rett Syndrome
- 7 Putting Into Perspective the Use of the Fmr1 Knockout Mouse as a Model for Autism Spectrum Disorder
- 8 Molecular Functions of the Mammalian Fragile X Mental Retardation Protein: Insights Into Mental Retardation and Synaptic Plasticity
- 9 Tuberous Sclerosis and Autism
- 10 <i>PTEN</i> and Autism With Macrocepaly
- 11 <i>SHANK</i> Gene Family and Autism
- 12 Smith-Lemli-Opitz Syndrome and Role of Cholesterol in Autism
- 13 Angelman Syndrome
- 14 Neuroligins and Neurexins: Bridging the Synaptic Cleft in Autism
- 15 Alterations of the Serotonin–Melatonin Pathway in Autism Spectrum Disorders: Biological Evidence and Clinical Consequences
- 16 <i>CNTNAP2</i> and Autism Spectrum Disorders
- 17 Chromosome 15q11.2q13.3 Aneusomies and Autism Spectrum Disorders
- 18 Oxytocin and Vasopressin: Mechanisms for Potential Sex Differences Observed in Autism Spectrum Disorders
- 19 FOXP2: Linking Language and Autism
- Index