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Pharmacology of Neural Blockade 

Pharmacology of Neural Blockade
Chapter:
Pharmacology of Neural Blockade
Author(s):

Christopher M. Duncan

and Paula A. Craigo

DOI:
10.1093/med/9780199743032.003.0002
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date: 18 May 2021

Chapter 2 reviews the mechanism of action for local anesthetics. Clinical features such as potency, onset of action, duration, and dose are discussed. Drug metabolism, toxicity (local and systemic), and its treatment are included. The chapter concludes with additional information on adjuvant medications (eg, epinephrine, clonidine) used to extend or enhance the clinical effects of local anesthetics.

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