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Myopathies 

Myopathies
Chapter:
Myopathies
Author(s):

Jun Kimura

DOI:
10.1093/med/9780199738687.003.0027
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date: 31 July 2021

Myopathies comprise muscular dystrophy, congenital myopathy, metabolic myopathy, endocrine myopathy, myositis, and those associated with general medical conditions,including critical illness myopathy. Despite the advent of gene analysis, the diagnostic use of electrophysiologic technique still has its place as a screening test. Needle studies contribute not only in differentiating myogenic from neurogenic paresis but also in delineating the distribution of myopathic abnormalities. The patterns classically associated with myopathy may occasionally result from neurogenic involvement in late stages. Nerve conduction studies may mimic a neuropathic process of the motor axons with a reductionof compound muscle action potentials and preservation of sensory nerve potentials. This chapter describes a simplified overview of the major disorders commonly encountered in an electrophysiologic laboratory with emphasis on clinical and physiologic features rather than the molecular mechanism.

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