Show Summary Details
Page of

Myasthenia Gravis, Myasthenic Syndrome, and Related Disorders 

Myasthenia Gravis, Myasthenic Syndrome, and Related Disorders
Myasthenia Gravis, Myasthenic Syndrome, and Related Disorders

Jun Kimura

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 20 September 2021

This chapter deals with clinical and electrodiagnostic aspects of myasthenia gravis, myasthenic syndrome, and related disorders such as botulism and tick paralysis. In disorders of neuromuscular transmission, morphologic abnormalities correlate with physiologic alterations in the kinetics of acetylcholine release, which in turn diminishes twitch strength. Accumulated evidence clearly implicates the postsynaptic acetycholine receptors as the site of pathology in myasthenia gravis. In contrast, presynaptic defects of ACh release characterize the Lambert-Eaton myasthenic syndrome and botulism. Although such a dichotomy helps simplify the classification of pathogenesis, the exact physiologic or morphologic basis of various myasthenic syndromes remains unknown. These additional diseases affect the complex process of chemical transmission at different steps, as exemplified by the original case of a congenital defect of acetylcholine esterase.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.